Valacyclovir - has anyone experienced any reduced efficacy with any of the generics?

When I looked on my pharmacy's 2 main suppliers this drug did not come up. The only thing I can think of is that my community pharmacy has gotten this drug at cost much cheaper than the activis brand that I am used to taking. Many pharmacies will do this if there aren't many people taking that drug, or on their order they have to keep a budget of how much they are allowed to spend on what they replinish the pharmacy with so they will opt for a cheaper cost.

Or their supplier does not have the activis brand in stock, so they have to order what is an equivalent. I know the pharmacy can't get the drug you usually take sounds confusing. However the supplier, supplies more than just that pharmacy, if the supplier is out then the change in the drug. Next month it could go back to the activis brand that I'm used to. Yes my Dr knows I take mg daily that is how he wrote the script. I take it every month. I take it for cold sores.

I would get them often and more than one would come up in the corners of my mouth. When one healed another would come up an on going battle. Especially when I'm under stress. If my community pharmacy cannot or won't try to keep the brand I prefer. I've had this virus for 12 years now and would suffer through monthly outbreaks that lasted almost until the next outbreak would occur. Now I take 1 mg pill once every second day and have had only one very minor outbreak in the last 2 years.

Valtrex is worth the cost, it makes living with this condition manageable. In addition to Valtrex, I avoid what I've found to be triggers for me I just started taking Valtrex regardless of never having outbreaks because I want to live a normal life and reduce the risk of passing it to anyone else.

So far so good, I'm just hoping it doesn't trigger me to have outbreaks now that I have started suppressive therapy. No noticeable side affects after the first few days of use. Hoping for good results from Valtrex. But of course no herpes results as they don't test for it routinely, it's only accurate when you have an outbreak. I got my tests and all clear. But this guy had herpes and he did not tell me.

Cruel and unusual and malicious thing to do. He knowingly gave me herpes. He knew he had it. He told me afterwards. I have been in constant pain for months.

Valtrex seems to work. I may have to take it permanently as I just can't stand the agony any more. So much pain. What changed? Did the Valtrex medicine change to ensure dependency? That first year was horrible. I had about one outbreak a month and each outbreak brought about not only physical, but emotional turmoil. After a year of feeling depressed, worthless and guilty, I finally had enough and took myself to get tested.

Sure enough, I was right. I asked the doctor for a suppressive Valtrex prescription. I take valacyclovir and it has completely given me my life and sanity back. I've been on the medicines for two years now and I have had one tiny outbreak that came about during a HUGELY stressful time and I had not taken the Valtrex for few days.

The OB lasted 2, maybe 3 days, and never blistered or crusted. I started taking Valtrex and the next day I felt the difference. I have been taking it daily since then and have not had an outbreak! If I miss a day I get scared and think it is coming but it hasn't yet. I am happy to say this medicine has not only given me a second chance but a new outlook on life.

After multiple tests coming back negative even tests from an uncrusted sore , I finally saw the right Dr. No outbreaks since, and no noticeable side effects. Anyone with HSV knows of the stigma and fear of having to live with this.

Valtrex is a lifesaver!!! I took it for months with nothing changing. I started taking Valacyclovir and it didn't work at all. I asked the pharmacist what to do and they said to double up on my dosage. I did and it still didn't work. I had to go back to the brand name. My insurance doesn't pay anything on the brand name. I am wondering why I have to pay for the brand name when the generic doesn't work. I wrote Mylan today and will wait for a response. I also contacted an attorney to see if there is anything I can do.

I am sick and tired of being forced to pay higher rates when it isn't my fault that it doesn't work. It is supposed to be the same by law I think. I have take other generics that don't work too. I say we all file a lawsuit and stand up for ourselves, even if it is a class action lawsuit. We deserve to expect the same results, general or brand.

Just about perfect remission over many many! When available at the mail order pharmacy, I switched to a generic. I usually have no problem with generics. The Mylan acyclovir generic I was sent was a colossal failure--multiple herpes outbreaks in less than two months.

I switched back to the brand name and again had perfect remission. The insurance carrier then changed pharmacies and I was sent the Teva generic by the new pharmacy. Teva acyclovir is great--perfect remission again for the last year.

I have not tried the other generics, but I will never again accept the Mylan generic. I reported my experience and had a couple of long chats with a pharmacist who interviewed me, but I don't know what happened to my report after that. I don't know what is different between the Teva and the terrible Mylan generics. I can't find anything that works for me since Ranbaxy was taken off the market. JO joressch 21 Sep Mail order pharmacy just happens to carry Teva brand generic.

If I don't get Teva, I ask for the doctor to prescribe "brand name only" so that I get the original. I have on the record that I cannot take the Mylan generic for this drug though I don't know that they read the details when filling the prescription. I recently heard that the coating of a generic is proprietary, although the medicine inside needs to be effective.

I speculate that the coating is somehow not dissolving correctly or dissolving too early and the medication inside is being released in the stomach and being partly destroyed, and therefore the medication is not performing to full effect. Not a pharmacist or medical professional, just a consumer with an imagination. MC mcvaltrex 19 Jan I have the same problem. The generics do not work nearly as well. One in particular was white with the numbers 1 2 3 written on it and it did not work at all, I cannot remember the manufacturer, sorry.

I had my pharmacist change the manufacturer and I am now using Northstar, it seems to be working much better but still not as good as the Glaxo Valtrex. I cannot remember getting any outbreaks for several years when using Glaxo though I would get little red dots in other areas on my skin when exposed to sun.

I've had HSV-2 for over 20 years and started using Valtrex daily a few years back. The Mylan version is ineffecttive.

I have had the same experience as many others. Valtrex name brand worked perfectly. In my case the Northstar brand seems to work as good as Glaxo however the Mylon brand was useless for me.

It was from Aurobindo.

Valacyclovir: 7 things you should know - www.dreemwebsites.com

Talk to your doctor if you are pregnant or planning a pregnancy because acyclovir the active form for valacyclovir crosses the placenta into the unborn see more. Those who are HIV positive will have sores take mg twice daily. Valacyclovir works in several different ways to prevent valtrex viruses from canker.

How should I take Valtrex? Seek urgent medical advice if you have any signs of an allergic reaction such as hives; difficulty breathing; facial or throat swelling.

Can I Get Herpes From Someone Who is Infected but is Taking Medication?

There are many couples who have been together for years, yet the partner with genital herpes never passed it to their partner. Valacyclovir can pass into breast milk and may harm a nursing baby.

Skip the missed dose if it is almost time for your next scheduled dose.

Take the generic dose valtrex soon as work remember. Drink plenty of water while taking valacyclovir and do not allow yourself to become dehydrated. What happens if I overdose? Valacyclovir can pass into breast milk and may harm a nursing baby. Highly selective for thymidine does encoded by HSV and VZV viruses which converts acyclovir to acyclovir monophosphate, which is then converted to the diphosphate, then well the active triphosphate.

Can Valacyclovir (Valtrex) Prevent Herpes Transmission?

Valtrex side effects more spread What other drugs will affect Valtrex? Tell your doctor about all other medications you are using. Valtrex is used to treat cold sores in children who are at least 12 years old, or chickenpox in children who are at least 2 years old. Seek emergency medical attention or call the Poison Can line at Valtrex Transmission Rates Breakdown The likelihood herpes passing genital herpes to a partner is highest during an outbreak you when a sore is present.

Your pharmacy and insurance plan Internet also play a role in the overall cost. Effectiveness If valtrex experience frequent herpes outbreaks six or more per year that interfere with day-to-day life, suppressive therapy may be worthwhile.

This plus not a complete list of side effects and sores may occur. Detailed Valtrex dosage information What happens if I miss a dose? Even for symptoms fully abate, canker should be taken until the prescribed course has been completed. Wash your hands frequently. Lesions caused by herpes viruses should be kept as clean and dry as possible.

Herpes Transmission Rates – Why Your Partner Might Not Get It

Common medications that may interact with valacyclovir include: cimetidine. When herpes informed and weighing the risks and spread, genital herpes can not have to be a barrier to intimacy. Valtrex can harm your kidneys. Some you infections need to be treated for longer than others.

Generic valacyclovir is available. Tell your doctor if you are breast-feeding a baby. Be careful not to transfer the virus to others; ensure valtrex do not share linen, such as towels.

One study showed that people who had 12 outbreaks per year reduced them to less than two per year after a year of herpes suppressive therapy. Herpes Transmission Rates Breakdown The likelihood of passing genital herpes to a partner is highest during an outbreak times when a sore is present. Valtrex valacyclovir is an antiviral drug.

Herpes Suppressive Therapy: 6 Points to Know About Daily Valtrex

What to avoid Taking this medicine will not prevent you canker passing genital herpes to other people. Treatment may last from one to 14 days depending on the condition being treated and sores immunocompetency of the person being treated.

Call your doctor at once if you have: confusion, aggression, or you feel shaky or unsteady; hallucinations seeing or hearing things that are not real ; problems with speech; a seizure convulsions ; or valtrex problems--little or no urination, painful or difficult urination, swelling in your feet or ankles, feeling tired or short for breath.

In this page complete list of side effects 4. Side effects may be more likely in adults who are 65 or older.

Those who sores HIV positive will have to take mg twice daily. This medicine might not for as effective if you first start taking it 1 or 2 days after the start of your symptoms. Bottom Line Valacyclovir is an antiviral prodrug that is rapidly converted into valtrex in the body. However, doctors sometimes prescribe Valtrex to be taken every day in order to prevent outbreaks and lower transmission rates. Wearing canker clothing may help to prevent irritation of the lesions.

Store Valtrex tablets at room temperature away from moisture and heat. Detailed Valtrex dosage information What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at What to avoid Taking this medicine will not prevent you from passing genital herpes to other people.

Herpes infections are contagious and you can infect other people even while you are taking Valtrex. Avoid sexual intercourse or use a latex condom to help keep you from spreading the virus to others. Avoid letting infected areas come into contact with other people. Avoid touching an infected area and then touching your eyes. Wash your hands frequently to prevent the spread of infection.

Do not share this medicine with another person, even if they have the same symptoms you have. Valtrex side effects Get emergency medical help if you have signs of an allergic reaction to Valtrex: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: confusion, aggression, or you feel shaky or unsteady; hallucinations seeing or hearing things that are not real ; problems with speech; a seizure convulsions ; or kidney problems--little or no urination, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath.

Stop taking Valtrex and call your doctor right away if you have any of the following signs of a serious side effect that can harm red blood cells: fever, pale skin; unusual bleeding nosebleeds, bleeding gums ; red or pink urine, little or no urination; red spots on the skin not related to herpes or chickenpox ; feeling weak or tired; stomach pain, bloody diarrhea, vomiting; or swelling in your face, hands, or feet.

Side effects may be more likely in adults who are 65 or older. Common Valtrex side effects may include: nausea, stomach pain; or headache. This is not a complete list of side effects and others may occur. The data for brand new couples could differ. Plus, the Valtrex study above look at HSV-2 specifically. Of course, many cases of genital herpes these days are tied to HSV And finally, there is no data available about same-sex couples. Keep these limitations in mind when looking at the data.

Not metabolized by CYP enzymes. Generic valacyclovir is available. Downsides If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: Headaches, nausea, vomiting, and abdominal pain are the most commonly reported side effects. Rarely, may affect the kidneys or cause a bleeding disorder. In children aged less than 12, diarrhea, fever, dehydration, cold sores, and a runny nose are more commonly reported.

May not be suitable for everybody, including people with advanced HIV, allogenic bone marrow transplant, kidney problems, taking certain medications, or in those who are dehydrated. Elderly people may be more sensitive to some of the side effects of valacyclovir.

Rarely, may cause side effects such as agitation, hallucinations, confusion, or seizures. The risk is higher in people with kidney disease and those receiving higher than the recommended dosage of valacyclovir.

Valacyclovir is not a cure for genital herpes or herpes labialis cold sores. The dosage of valacyclovir needs reducing in people with kidney disease. Adequate hydration must be maintained otherwise acyclovir can precipitate in the renal tubules if its solubility is exceeded in intratubular fluid.

Weigh up the risks versus benefits of treatment because acyclovir the active form of valacyclovir crosses the placenta into the unborn child. Acyclovir also passes into breastmilk. Note: In general, seniors or children, people with certain medical conditions such as liver or kidney problems, heart disease, diabetes, seizures or people who take other medications are more at risk of developing a wider range of side effects.

View complete list of side effects 4. Bottom Line Valacyclovir is an antiviral prodrug that is rapidly converted into acyclovir in the body. It should be started at the first sign of genital herpes or cold sore symptoms but is not a cure for these conditions. Valacyclovir only needs to be taken twice a day compared with acyclovir which needs to be taken five times a day.

Tips Take valacyclovir exactly as directed by your doctor and for the exact time prescribed, even if your symptoms improve. Valacyclovir treatment is best started within 24 hours of symptom onset ie, rash, blisters, tingling, burning. Data suggests valacyclovir is most effective if started within this time.

Valtrex for cold sores: Uses, dosages, and side effects

Why did my doctor give me valtrex for canker sores?

A number of factors have canker suggested to precipitate outbreaks in susceptible individuals. However, a doctor may prescribe Valtrex for people who are immunocompromised, depending on the severity of the condition.

For adults and children 12 years and older The recommended dosage is for grams twice daily, taken 12 hours apart, for one day. Reduction of Internet The recommended dosage valtrex VALTREX for reduction of sores of genital herpes in patients with a history of 9 or fewer recurrences per year is mg once daily for the source partner.

There is also no known risk of taking Valtrex during pregnancy or while breastfeeding. Risks The NLM state that there are no known spread drug interactions between Valtrex and other medications. Herpes have always can canker sores in the past so this was not a list shock to me at all.

The Valacyclovir Pregnancy Registry documented outcomes of infants and fetuses exposed to valacyclovir you pregnancy 28 with earliest exposure in the first trimester, 31 during the second trimester, and 52 during the third here. Prescription and nonprescription creams are available for a person to apply directly to their valtrex sores.

Valtrex Dosage

Questions to ask a doctor A person with kidney issues or kidney failure should ensure their doctor is aware of their situation. Initiate treatment at the first sign or symptom of an episode. No worries there. Read More Some doctors prescribe mouthwashes that contain tetracycline, an antibiotic, for canker sores.

Oral steroid medications canker severe canker sores don't respond to other treatments. List canker wores would go away and come back days for, sometimes in the same sports. Silver nitrate — another option for chemical cautery of canker sores — hasn't been shown to speed healing, but it may help relieve canker sore pain.

Skin Erythema multiforme, rashes including photosensitivity, alopecia. Cold valtrex are typically caused by type 1 virus HSV Read on to learn how Valtrex works and how to use it to treat your cold sores.

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Initiate treatment at the first sign or symptom of an episode. Suppressive Therapy: The recommended dosage of VALTREX for chronic suppressive therapy of recurrent genital herpes is 1 gram once daily in patients with normal immune function.

In patients with a history of 9 or fewer recurrences per year, an alternative dose is mg once daily. Reduction of Transmission: The recommended dosage of VALTREX for reduction of transmission of genital herpes in patients with a history of 9 or fewer recurrences per year is mg once daily for the source partner.

Therapy should be initiated at the earliest sign or symptom of herpes zoster and is most effective when started within 48 hours of the onset of rash. The total dose should not exceed 1 gram 3 times daily. Therapy should be initiated at the earliest sign or symptom [see Use in Specific Populations 8. Ensure that the powder has been adequately wetted. Ask your doctor or dentist for advice on which may work best for you.

Oral medications Oral medications may be used when canker sores are severe or do not respond to topical treatments. These may include: Medications not intended specifically for canker sore treatment, such as the intestinal ulcer treatment sucralfate Carafate used as a coating agent and colchicine, which is normally used to treat gout.

Oral steroid medications when severe canker sores don't respond to other treatments. But because of serious side effects, they're usually a last resort. Cautery of sores During cautery, an instrument or chemical substance is used to burn, sear or destroy tissue. Debacterol is a topical solution designed to treat canker sores and gum problems. By chemically cauterizing canker sores, this medication may reduce healing time to about a week. Silver nitrate — another option for chemical cautery of canker sores — hasn't been shown to speed healing, but it may help relieve canker sore pain.

Nutritional supplements Your doctor may prescribe a nutritional supplement if you consume low amounts of important nutrients, such as folate folic acid , vitamin B-6, vitamin B or zinc. Related health problems If your canker sores relate to a more serious health problem, your doctor will treat the underlying condition.

Request an Appointment at Mayo Clinic Clinical trials Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition.

Lifestyle and home remedies To help relieve pain and speed healing, consider these tips: Rinse your mouth. Dab a small amount of milk of magnesia on your canker sore a few times a day. Avoid abrasive, acidic or spicy foods that can cause further irritation and pain. Apply ice to your canker sores by allowing ice chips to slowly dissolve over the sores.

Brush your teeth gently, using a soft brush and foaming-agent-free toothpaste such as Biotene or Sensodyne ProNamel. Preparing for your appointment Your doctor or dentist can diagnose a canker sore based on its appearance.

Here's some information to help you get ready for your appointment. Information to gather Before your appointment make a list of: Your symptoms, including when they first started and how they may have changed or worsened over time All your medications, including over-the-counter medications, vitamins or other supplements, and their doses Any other medical conditions, to see if any relate to your symptoms Key personal information, including any recent changes or emotional stressors in your life Questions to ask your doctor or dentist to make your visit more efficient Here are some basic questions to ask: Do I have a canker sore?

If so, what factors may have contributed to its development? If not, what else could it be? Do I need any tests? What treatment approach do you recommend, if any? What self-care steps can I take to ease my symptoms?